Figure 1. Time course of bacteremia in mice infected with S. aureus at the LD₅₀ inoculum.

A Survival of infected mice (n = 25). B Mouse body weight, shown as mean ± SD (error bars). Body weight of non-surviving infected mice was significantly lower compared to surviving infected mice and to placebo-inoculated mice (P < 0.01; Quade’s rank analysis of covariance). C Discomfort score, shown as mean ± SD (error bars). Discomfort score -2: bad fur. Discomfort score -3: bad fur, hunched back. Discomfort score -4: bad fur, hunched back, instability, euthanasia needed. Placebo-inoculated mice (• n = 12), surviving infected mice (▪ n = 25), non-surviving infected mice (♦n = 25).