Table 1. Shh overexpression exacerbates Helicobacter gastritis.
| Founders | Average Fold Expression of Shh/NTG | Histology | ||
| Normal | Inflammation | Metaplasia | ||
| CMV-ShhWT (High Expressor) | 102.0 | 0/1 | 1/1 | 1/1 |
| CMV-ShhWT (Medium Expressor) | 6.8 (+/−1.9) | 0/3 | 3/3 | 0/3 |
| CMV-ShhWT (Low Expressor) | 0.78 (+/−0.3) | 5/5 | 0/5 | 0/5 |
| CMV-ShhF200H(High Expressor) | 82.5 | 1/1 | 0/1 | 0/1 |
| CMV-ShhF200H (Medium Expressor) | 19.5 (+/−9.3) | 7/7 | 0/7 | 0/7 |
| CMV-ShhF200H (Low Expressor) | 0.3 | 1/1 | 0/1 | 0/1 |
| H+/K+-β-ShhWT (Medium Expressor) | 5.23 (+/−0.6) | 1/3 | 2/3 | 2/3 |
| H+/K+-β-ShhWT (Low Expressor) | 1.62 (+/−0.3) | 6/6 | 0/6 | 0/6 |
| H+/K+-β-ShhF00H (Medium Expressor) | 13 | 1/1 | 0/1 | 0/1 |
| H+/K+-β-ShhF200H (Low Expressor) | 0.92 (+/−0.2) | 4/4 | 0/4 | 0/4 |
*
High expressor >70-fold; Medium expressor >3-fold; Low expressor <3-fold. Average transgenic expression for low-, medium- and high-expressing founders is indicated. The number of mice with normal gastric phenotype, inflammation or metaplasia is also indicated.