Table 1. Pharmacokinetic parameters for everolimus^a in humans and mice.

	Dose	Species	t½ (hr)	AUC0→t (ng·hr/mL)	Cmax (ng/mL)	Cmin (ng/mL)	Ref.
Everolimus a
	10 mg	Human	–	514±231	61±17b	13.3b	[25]
	10 mg	Human	–	711±113	66±1.4b	∼20bd	[26]
	5 mg	Human	–	238±77	32±9b	†5.4	[25]
	5 mg	Human	–	543±189	58±18b	∼12–14bd	[26]
	10 mg/kg	Mouse	5.0	11592	1684±277b	59±5b
	2.5 mg/kg	Mouse	6.0	1921	350±230b	12±6b
	5 mg/kge	Mouse	5.7	3716	561bc	21b

^aAll PK data obtained for everolimus is for daily oral administration.

^bSteady-state parameter.

^cValue of C_max for simulated data is taken at 0.5 h for comparison to data measured at this time.

^dData estimated from graph in references.

^eData for 5 mg/kg RAD001 is based on simulations.