Table 2. Pharmacokinetic parameters for Irinotecan/SN38 in humans and mice.

Dose	Species	Schedule	t½ (hr)	AUC0→t(ng·hr/mL)	Cmax(ng/mL)	Ref.
Irinotecan/SN38 (PK data is for SN38)
125mg/m2	Human	1.5 hr INF	10.4±3.1	229±108	26.3±11.9	[27]
340mg/m2	Human	1.5 hr INF	21.0±4.3	474±245	56.0±28.2	[27]
350mg/m2	Human	1 hr INF	23±35	931±948	88±26	[28]
350mg/m2	Human	1 hr INF	15±23a	609±531a	57±20a	[28]
125mg/m2	Human	1.5 hr INF	28.5	228±149	27±12	[29]
180mg/m2	Human	1.5 hr INF		222–245a		[30]
5mg/kg	Mouse	IV Bolus		279c	647	[39]
10mg/kg	Mouse	IV Bolus		534c	443	[39]
10mg/kg	Mouse	IV Bolus		533–759c	435–600b	[37]
10mg/kg	Mouse	IV Bolus		533–1029c	443–673b	[36]
10mg/kg	Mouse	IV Bolus	2.2	410±60 (t = 6 h)		[36]
20mg/kg	Mouse	IV Bolus	3.0	710±240 (t = 6 h)		[36]
40mg/kg	Mouse	IV Bolus	3.4	1080±110 (t = 6 h)		[36]

^aWeek 4 PK with cetuximab.

^bData estimated from graph in references.

^cAUC_0→∞was reported.