Table 2. Characteristics of prospective studies included in meta-analysis of published studies on serum magnesium concentrations and total CVD risk.
| Source | Location/Follow-up, y | Study Population(n) | Sex/Age, y | RecruitmentTime | Outcome(s) | Outcomes Assessment | Serum magnesium Assessment |
| Gartside (1995) | United States, 10 | 8251 | Female/Male, 25–74 | 1971–1975 | CVD | Adjudicated by hospital records and death certificates; classified according to ICD-9 (codes 390–459). | NA |
| Liao (1998) | United States, 7 | 13,922 | Female/Male, 45–64 | 1987–1989 | CHD | Ascertained by self-report and medical records, death certificates; reviewed by members of the ARIC Morbidityand Mortality Classification Committee | Measured the procedure of Gindler and Heth,and used the metallochromic dye calmagite. |
| Ford (1999) | United States, 19 | 12,340 | Female/Male, ≥25 | 1971–1975 | CHD, CVDdeath | Determined by the health care facility records and death certificate; classified according to ICD-9 (codes 410–414). | Measured by atomic absorptionspectrophotometry using the method ofHansen and Freier. |
| Leone (2006) | France, 18 | 4035 | Male 30–60 | 1980–1985 | CVD death | Determined by the death certificate classified according to ICD-9 (codes 390–459) and ICD-10 (codes I00–I99). | Measured by flame atomic absorptionspectrometry. |
| Ohira (2009) | United States, 15 | 14,221 | Female/Male, 45–64 | 1987–1989 | Stroke | Ascertained by self-report, local hospitals, state vital statistics offices; classified according to ICD-9(codes 430–438). | Based on the procedure of Gindler and Hethand used the metallochromic dye, calmagite. |
| Khan (2010) | United States, 20 | 3531 | Female/Male, 44.3±10 | 1971 | CVD, CVDdeath | Adjudicated by hospital records, medical office notes, and Framingham clinic visit notes. | Measured using a standard colorimetric assay. |
| Peacock (2010) | United States, 12 | 14,232 | Female/Male, 45–64 | 1987–1989 | CVD death | Ascertained by self-report, hospitals, and death certificates. | Performed at visits 1 and 2 and was based onthe procedure of Gindler and Heth usingthe metallochromic dye calmagite. |
| Reffelmann (2011) | Germany, 10.1 | 3910 | Female/Male, 20–79 | 1997–2001 | CVD death | Assessed by Sociodemographic and medical histories; defined with ICD-10 codes I10–I79. | Performed on the Siemens HealthcareDiagnostics using a modification of MTB complexiometricprocedure. |
MTB = methylthymol blue; NA = not available.