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. 2013 Mar 8;8(3):e57720. doi: 10.1371/journal.pone.0057720

Table 4. Subgroup analysis to investigate differences between studies included in meta-analysis.

Subgroup Cohorts (n) RR (95% CI) Q I2(%) P value P value for heterogeneity between subgroups
Dietary Magnesium Intake
Individual CVD outcomes
Stroke 7 0.87 (0.81, 0.93) 4.76 0 0.575
CHD 3 0.73 (0.60, 0.87) 3.63 17 0.305 0.060
CVD death 3 0.89 (0.79, 0.99) 10.95 73 0.012
Sex
Male 7 0.87 (0.74, 1.00) 14.34 58 0.026 0.048
Female 6 0.86 (0.76, 0.95) 6.79 26 0.237
Location
United States 8 0.80 (0.72, 0.88) 9.70 18 0.287
Europe 3 0.91 (0.83, 0.99) 4.84 59 0.089 0.050
Asian 2 0.87 (0.76, 0.97) 4.60 57 0.100
Distribution fractions
Quintile 8 0.87 (0.82, 0.93) 10.53 24 0.230 0.187
Quartile 4 0.74 (0.80, 0.90) 2.63 0 0.621
Serum Magnesium concentrations
Individual CVD outcomes
CVD & CHD 4 0.82 (0.73, 0.92) 6.82 41 0.145 0.021
CVD death 4 0.64 (0.52, 0.77) 0.42 0 0.935
Sex
Male & Female 6 0.79 (0.72, 0.88) 15.24 61 0.018 0.797
Only male 2 0.75 (0.44, 1.06) 0.55 0 0.458
Location
United States 6 0.80 (0.73, 0.88) 13.81 49 0.055 0.075
Europe 2 0.78 (0.71, 0.81) 0.00 0 1.000
Distribution fractions
Quartile 5 0.84 (0.75, 0.92) 0.09 46 0.087 0.069
Thirds 2 0.67 (0.52, 0.83) 11.04 0 0.766