Table 4. Subgroup analysis to investigate differences between studies included in meta-analysis.
Subgroup | Cohorts (n) | RR (95% CI) | Q | I2(%) | P value | P value for heterogeneity between subgroups |
Dietary Magnesium Intake | ||||||
Individual CVD outcomes | ||||||
Stroke | 7 | 0.87 (0.81, 0.93) | 4.76 | 0 | 0.575 | |
CHD | 3 | 0.73 (0.60, 0.87) | 3.63 | 17 | 0.305 | 0.060 |
CVD death | 3 | 0.89 (0.79, 0.99) | 10.95 | 73 | 0.012 | |
Sex | ||||||
Male | 7 | 0.87 (0.74, 1.00) | 14.34 | 58 | 0.026 | 0.048 |
Female | 6 | 0.86 (0.76, 0.95) | 6.79 | 26 | 0.237 | |
Location | ||||||
United States | 8 | 0.80 (0.72, 0.88) | 9.70 | 18 | 0.287 | |
Europe | 3 | 0.91 (0.83, 0.99) | 4.84 | 59 | 0.089 | 0.050 |
Asian | 2 | 0.87 (0.76, 0.97) | 4.60 | 57 | 0.100 | |
Distribution fractions | ||||||
Quintile | 8 | 0.87 (0.82, 0.93) | 10.53 | 24 | 0.230 | 0.187 |
Quartile | 4 | 0.74 (0.80, 0.90) | 2.63 | 0 | 0.621 | |
Serum Magnesium concentrations | ||||||
Individual CVD outcomes | ||||||
CVD & CHD | 4 | 0.82 (0.73, 0.92) | 6.82 | 41 | 0.145 | 0.021 |
CVD death | 4 | 0.64 (0.52, 0.77) | 0.42 | 0 | 0.935 | |
Sex | ||||||
Male & Female | 6 | 0.79 (0.72, 0.88) | 15.24 | 61 | 0.018 | 0.797 |
Only male | 2 | 0.75 (0.44, 1.06) | 0.55 | 0 | 0.458 | |
Location | ||||||
United States | 6 | 0.80 (0.73, 0.88) | 13.81 | 49 | 0.055 | 0.075 |
Europe | 2 | 0.78 (0.71, 0.81) | 0.00 | 0 | 1.000 | |
Distribution fractions | ||||||
Quartile | 5 | 0.84 (0.75, 0.92) | 0.09 | 46 | 0.087 | 0.069 |
Thirds | 2 | 0.67 (0.52, 0.83) | 11.04 | 0 | 0.766 |