Fig. 2.

Changes of bone mineral density (BMD) at multiple sites at the end of Phase I (10 weeks) and Phase II (18 weeks) in normonatremic (open bars) and hyponatremic (black bars) aged F344BN rats. The rate of BMD decreases from baseline were significantly faster in the hyponatremic rats than in the normonatremic rats (p < 0.001). During Phase II, hyponatremic rats received high dose vitamin D supplement that mitigated further declines of BMD. Asterisks indicate statistically significant differences from the normonatremic controls. All data are means ± SEM