Fig. 2.

a Smoothed hazard estimates of mild cognitive impairment (MCI) according to cumulative exposure to angiotensin-converting enzyme inhibitors (ACE-Is) as a class and b cumulative exposure to enalapril and captopril compared with those who were exposed to other antihypertensive drugs. Italian Longitudinal Study on Aging, 1992–1996. The asterisk means that the analysis time (time unit: years) indicates the time at risk of the study population. The beginning of time at risk has been stated at the age of 65 years old, respecting the lower limit in age range of participants to the study. The analysis of time exceeds 85 years, indicating that some individuals who remained at risk have passed the age of 85 years. The figure is derived from a model that is adjusted for several parameters (Model 2 in Table 2)