Table 1.
Subject characteristics.
|
|
Previous Chelation
|
Starting Doses on Study
|
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|---|---|---|---|---|---|---|---|---|---|---|
| UPN | Age (years) | Ferritin (ng/ml) | LIC (mg/g) | T2* (ms) | DFO1(mg/kg) | Days/week | DFX (mg/kg) | DFO1(mg/kg) | Days/week | DFX (mg/kg) |
| Group A | ||||||||||
|
| ||||||||||
| A1 | 28 | 1253 | 3.9 | 19.5 | 41 | 7 | -- | 41 | 3 | 21 |
| A2 | 14 | 1050 | 4.1 | 6.5 | 37 | 7 | 9 | 43 | 3 | 19 |
| A3 | 29 | 1510 | 7.1 | 19.4 | 44 | 6 | -- | 44 | 3 | 22 |
| A4 | 36 | 1970 | 7.1 | 26.2 | 43 | 3 | -- | 43 | 3 | 21 |
| A5 | 14 | 2050 | 7.3 | 35.2 | 41 | 6 | -- | 41 | 3 | 20 |
| A6 | 26 | 1579 | 8.2 | 26.4 | 32 | 3 | -- | 32 | 3 | 20 |
| A7 | 27 | 1370 | 10.8 | 32.3 | 29 | 3 | 10 | 29 | 3 | 21 |
| Median | 27 | 1510 | 7.1 | 26.2 | ||||||
| Range | 14-36 | 1050-2050 | 3.9-10.8 | 6.5-35.2 | ||||||
|
| ||||||||||
| Group B | ||||||||||
|
| ||||||||||
| B8 | 12 | 5230 | 14.7 | 32.7 | 31 | 3 | 27 | 46 | 3 | 27 |
| B9 | 9 | 1000 | 17.3 | 28.7 | 33 | 7 | -- | 33 | 5 | 19 |
| B10 | 11 | 2879 | 17.4 | 22.0 | 35 | 3 | 26 | 35 | 3 | 26 |
| B11 | 24 | 5055 | 19.3 | 45.4 | 59 | 6 | -- | 49 | 6 | 20 |
| B12 | 9 | 1620 | 20.3 | 32.7 | 35 | 2 | 35 | 35 | 5 | 29 |
| B13 | 29 | 4680 | 21.7 | 6.7 | 45 | 3 | 31 | 45 | 6 | 31 |
| B14 | 20 | 4050 | 33.5 | 32.6 | -- | -- | 23 | 31 | 3 | 23 |
| B15 | 9 | 7660 | 34.4 | 3.6 | 36 | 6 | -- | 36 | 7 | 18 |
| B16 | 19 | 4750 | 34.8 | 36.8 | -- | -- | 30 | 45 | 5 | 25 |
| B17 | 18 | 10700 | 38.0 | 33.5 | 48 | 3 | -- | 48 | 5 | 21 |
| B18 | 12 | 6927 | 38.2 | 8.0 | -- | -- | 40 | 35 | 3 | 23 |
| Median | 12 | 4750 | 21.7 | 32.6 | ||||||
| Range | 9-29 | 1000-10700 | 14.7-38.2 | 3.6-45.4 | ||||||
1
Six subjects were using both chelators prior to starting the study as described in the text
2
DFO mg/Kg per infusion; three subjects (A4, A6 and B17) were infusing DFO on 3 days per week instead of the prescribed 5 days per week