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A β-hairpin loop identified in a protein crystal structure (left) can be transplanted onto a d-Pro- l-Pro template (right), resulting in cyclic β-hairpin mimetic (center). The template in the mimetic helps to stabilize folded β-hairpin conformations and fixes the hairpin register. A comparison of one NMR structure of a CDR loop mimetic (blue) with the same loop in the protein crystal structure is shown (right) [20].
