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β-Hairpin mimetics have been discovered that bind with high affinity to the targets shown. The complexes with the Fc fragment (A) and trypsin (C) are computer models based upon crystal structures of target-bound phage (1DN2) or natural product (1SFI) leads. The complexes shown with TAR RNA (2KDQ) (B), HDM2 (2AXI) (D), and CXCR4 (3OE0) (E) are crystal or NMR structures, available in the Protein Data Bank database.
