Figure 7.

Design of four β-hairpin mimetics (called IY, IF, HF, and HY) based upon V3-derived peptides bound to four different neutralizing mAbs [163]. The hairpin loops have different hairpin registers in the four complexes. The hairpin registers are fixed after transfer to the d-Pro- l-Pro template. For each, the left side shows the bound V3 loop conformation taken from the Protein Data Bank file, and the right side shows one typical NMR structure of each mimetic. The template is shown in orange at the bottom of each structure.