Figure 6.

Ability of VANGL2^R259L variant to rescue the convergent extension defect in zebrafish embryos treated with tri-MO. Panel A, lateral views of 2 days post fertilization zebrafish including uninjected wild-type and fish injected with either tri-MO alone, or tri-MO+VANGL2 or tri-MO+VANGL2^R259L. Panel B, statistical analyses of the body length measurements of all 4 groups indicated above. The Kruskal-Wallis test was used to compare differences between experimental groups (P<0.001 for tri-MO vs uninjected; P<0.05 and P<0.01 for VANGL2 and VANGL2^R259L as compared to the tri-MO alone respectively).