Table 1.
Genotype-phenotype studies of the Lpm2Jus looptail mutant
| R259L genotype at the Vangl2 locus | Phenotype
|
||||
|---|---|---|---|---|---|
| Looped or kinky tail | Spina bifida | Imperforate vagina | Male infertility | ||
| Adult (n=241) | 36 +/+, 141 +/- (99 ♀, 78 ♂) | 0 | NA | 0 | 0b |
| 64 -/- (27 ♀, 37 ♂) | 30 (47%) | NA | 21 (78%) | 12 (32%) | |
| E16.5-E18.5 (n=156) | 37 +/+, 69 +/- | 0 | 0 | NA | NA |
| 50 -/- | 16 (32%) a | 6 (12%) | NA | NA | |
a
This frequency could be underestimated due to the difficulty in visual examination of the looped or kinky tail in embryos.
b
Absence of male infertility is confirmed only in 4 +/+ and 29 +/- males included in the breeding scheme.