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. 2013 Mar 1;52(2):112–119. doi: 10.3164/jcbn.12-95

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Copyright © 2013 JCBN

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 4 — The relative expression of p65 mRNA and APE-1 mRNA by real-time PCR in KYSE220 stimulated by MCP-1 with or without pretreatment of MG-132. Control: unstimulated KYSE 220 cells; MG-132: KYSE220 cells treated with MG-132; MCP-1: MCP-1 stimulated KYSE 220 cells; MCP-1 + MG-132: MCP-1 stimulated KYSE 220 cells pretreated with MG-132. MCP-1 (0.1 µM) significantly induced the upregulation of p65 mRNA, which was abrogated by pretreatment of MG-132 (1 µM) (p<0.001; p<0.001, respectively; A). MCP-1 (0.1 µM) significantly induced the upregulation of APE-1 mRNA, which was abrogated by pretreatment of MG-132 (1 µM) (p<0.001; p<0.001, respectively; B). The results are representative of three separate experiments. Data are expressed as mean ± SD. (*p<0.001).