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. 2013 Mar;15(3):249–262. doi: 10.1593/neo.121950

Figure 6.

Figure 6

RMFs suppress, while CAFs enhance, the metastatic potential of malignant cells in vivo. Graphs of fold change in (A) the number of metastatic foci per lung or (B) lung luminescence as a measure of total pulmonary metastatic burden in the presence of RMFs (in blue from left to right: 163, 156, 9, 146) or CAFs (in red from left to right: 1366, 559, 1363) relative to the 231-Lux cells alone for all experiments combined. The number of mice in each group and the P values comparing the effects of each RMF and CAF on metastatic burden relative to the 231-Lux cells alone are shown in Table 3.