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Dual treatment with the anti-HER3 D1 Ab 16D3-C1 and trastuzumab (●) improves tumor growth inhibition in nude mice xenografted with HER2low A431 epidermoid (A) or A549 lung (B) carcinoma cells in comparison to mice treated with vehicle (NaCl; ◆), 16D3-C1 (▵) or trastuzumab (○) alone. Tumor growth data are presented as the mean tumor volume ± SEM for each group of eight nude mice.
