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The anti-HER3 Abs block NRG-stimulated BxPC3 pancreatic cancer cells in the G1 phase of the cell cycle (A), inhibit their proliferation (B), and promote cell apoptosis (C). Cell cycle progression was analyzed using propidium iodide staining; cell proliferation was quantified on the basis of the cell incorporation of Alexa Fluor 488-conjugated 5-ethynyl-2′-deoxyuridine, and apoptosis was demonstrated by staining with Annexin V and 7-aminoactinomycin D.
