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. 2013 Jan 7;4(1):29–39. doi: 10.1111/jphs.12004

Table 4.

Rate of events: negative binomial regression results by adherence and persistence status

Adherenta Persistenta
Event Setting IRRb 95% CIs P value IRRb 95% CIs P value
Number of psychiatric-related relapse events 0.90 0.86 0.94 <0.001 0.88 0.84 0.92 <0.001
Number of schizophrenia-related inpatient admissions 0.94 0.85 1.03 0.186 0.85 0.77 0.93 <0.001
Number of inpatient admissions 0.97 0.91 1.03 0.276 0.87 0.82 0.93 <0.001
Number of schizophrenia-related outpatient visits 1.20 1.00 1.43 0.046 1.15 0.97 1.36 0.118
Number of outpatient visits 1.29 1.19 1.40 <0.001 1.27 1.17 1.38 <0.001
Number of schizophrenia-related ED visits 0.79 0.69 0.90 <0.001 0.81 0.71 0.92 0.002
Number of ED visits 0.73 0.67 0.78 <0.001 0.78 0.73 0.85 <0.001
Number of schizophrenia-related office visits 2.10 1.70 2.58 <0.001 1.89 1.54 2.32 <0.001
Number of office visits 1.47 1.35 1.61 <0.001 1.44 1.32 1.57 <0.001
Number of schizophrenia-related prescription claims 1.99 1.91 2.06 <0.001 1.91 1.84 1.98 <0.001
Number of prescription claims 1.81 1.73 1.88 <0.001 1.74 1.67 1.82 <0.001
Number of schizophrenia-related ancillary care encounters 1.85 1.65 2.09 <0.001 1.65 1.47 1.86 <0.001
Number of ancillary care encounters 1.75 1.63 1.88 <0.001 1.57 1.46 1.68 <0.001
Number of schizophrenia-related total non-pharmacy medical encounters 1.78 1.63 1.94 <0.001 1.59 1.46 1.73 <0.001
Number of total non-pharmacy medical encounters 1.51 1.44 1.59 <0.001 1.41 1.34 1.48 <0.001
Number of schizophrenia-related total medical encounters 1.87 1.76 1.98 <0.001 1.70 1.60 1.80 <0.001
Number of total medical encounters 1.65 1.58 1.71 <0.001 1.55 1.50 1.62 <0.001
a

Psychiatric-related relapse event rates and all-cause and schizophrenia-related visits (to the selected service settings) compared among patients adherent (MPR ≥ 80%) and non-adherent (MPR < 80%) to SGOAs and persistent (continuous use defined as no refill gap or refill gap of ≤60 days for SGOA medication) and non-persistent (refill gap for the SGOA medication > 60 days or SGOA discontinuation) with SGOAs.

b

IRR based on negative binomial regression model adjusted for age, gender, race/ethnicity, health plan, eligibility status, dose escalation, polypharmacy, mental health substance abuse coverage, Charlson Comorbidity Index score and adherence or persistence.

CI, confidence interval; ED, emergency department; IRR, incident rate ratio; MPR, medication possession ratio; SGOA, second-generation oral antipsychotic.