Table 6.

Risk of BPAR at one yr and graft loss at one yr after adjustment for confounding variables (Cox regression analysis)

	HR	95% CI	p Value
BPAR at one yr
MPA dose change
Tacrolimus exposure included as a covariable	2.60	1.28–5.29	0.008
Tacrolimus exposure not included as a covariable	2.58	1.28–5.23	0.008
Reduced tacrolimus exposure	0.83	0.45–1.53	0.545
Graft loss at one yr
MPA dose change
Tacrolimus exposure included as a covariable	2.23	1.01–4.89	0.047
Tacrolimus exposure not included as a covariable	2.16	0.99–4.79	0.054
Reduced tacrolimus exposure	1.17	0.56–2.44	0.684

HR, hazard ratio; CI, confidence interval; MPA, mycophenolic acid; BPAR, biopsy-proven acute rejection.

MPA dose change included dose reduction, interruption, or discontinuation.