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. Author manuscript; available in PMC: 2013 Mar 11.
Published in final edited form as: In Vivo. 2011 Nov-Dec;25(6):861–869.

Figure 6.

Figure 6

Longitudinal histopathology of esophagus of nonirradiated and irradiated NOS1−/− and C57BL/6NHsd mice. Once extracted, the esophagi were fixed in 10% buffered formalin, sectioned (5 mm), and subsequently stained with hematoxylin and eosin (H&E) for histological analysis. A: Nonirradiated C57BL/6NHsd mouse esophagus (×500). B: Nonirradiated NOS1−/− mouse esophagus (×500). C: C57BL/6NHsd mouse esophagus at day 8 following 9.5 Gy (TBI) (×500), showing moderate edema and atrophy of both inner circular and outer longitudinal muscle layers. D: NOS1−/− mouse esophagus at day 8 after 9.5 Gy TBI showing necrosis of outer circular muscle layer (arrow) (×100).