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. 2013 Mar 5;17(3):399–410. doi: 10.1016/j.cmet.2013.02.005

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© 2013 ELL & Excerpta Medica.

Open Access under CC BY 3.0 license

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GRSF1 Interacts and Colocalizes with RNase P in Mitochondrial RNA Granules

(A) Coimmunoprecipitation of MRPP1-FLAG and GRSF1-HA expressed in HEK293T cells. Pull-down was performed with FLAG antibodies or control IgG (IgG). OPA1 was used as a negative control.

(B) Confocal analysis of HeLa cells transfected with MRPP1-FLAG, labeled with BrU, and immunolabeled with anti-FLAG and anti-BrU antibodies. Arrowheads, foci formed by BrU in mitochondria. Bottom panels, magnification.

(C) Confocal analysis of HeLa cells transfected with MRPP1-FLAG, GRSF1-HA, and mitoECFP and immunolabeled with anti-FLAG and anti-HA antibodies. Arrowheads, foci formed by GRSF1 in mitochondria. Bottom panels, magnification.

(D) Confocal analysis of HeLa cells transfected with MRPP3-MYC, GRSF1-HA, and mitoECFP and immunolabeled with anti-MYC and anti-HA antibodies. Arrowheads, foci formed by GRSF1 in mitochondria. Bottom panels, magnification.