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ARRY-520 induces G2M cell cycle block prior to cell death. ARRY-520 (1 nM) induced significant G2M cell cycle block in OCI-AML3 cells at 24 hours (A). Cell cycle distribution at different time points in OCI-AML3 cells treated with ARRY-520 (B). Annexin V positivity at different time points in OCI-AML3 cells treated with ARRY-520 (C).
