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. Author manuscript; available in PMC: 2013 Mar 11.
Published in final edited form as: Leukemia. 2009 May 21;23(10):1755–1762. doi: 10.1038/leu.2009.101

Figure 7.

Figure 7

ARRY-520-induced cell death is mediated via the mitochondrial apoptotic pathway. HL-60 and HL-60Bcl-2 cells were treated with ARRY-520. Cell cycle distribution was determined at 24 hours by PI staining, changes in MMP at 24 hours by CMXRos and MitoTracker Green staining, and apoptosis by annexin V/7-AAD staining (A). HL-60 and HL-60Bcl-2 cells were treated with ARRY-520, ABT-737, or both and cell death was determined at 24 hours by annexin V/7-AAD staining (B). HL-60 cells were treated with 10 nM ARRY-520 for various time points, and Bim and caspase-3 levels were determined by western blot analysis (C). ABT, ABT-737; AR, ARRY-520.