Figure 3.

Effect of AGEs on ATP-induced Ca²⁺ signaling in BAEC. (A) In the presence of extracellular Ca²⁺, AGEs alone induced an increase in [Ca²⁺] and inhibited the subsequent ATP-induced Ca²⁺ increase, as shown in the inset (Area Under Curve data). (B) In the absence of extracellular Ca²⁺, AGEs alone induced an increase in [Ca²⁺], inhibited ATP-induced intracellular Ca²⁺ release but did not affect CCE upon the re-addition of extracellular Ca²⁺ (CaCl₂). Points and columns represent the mean ± SEM of five to six recordings. *Indicates significant effect of AGEs compared to control (P < 0.05, t-test).