Figure 4.

Effect of AGEs on Ca²⁺ signaling in BAEC. (A) In the absence of extracellular Ca²⁺, AGEs alone induced an increase in [Ca²⁺] and induced significant CCE compared with control (unglycated BSA). (B) In the absence of extracellular Ca²⁺, AGEs added to the BAEC after ATP did not induce an increase in [Ca²⁺], but increased CCE (CaCl₂). Points and columns represent the mean ± SEM of six recordings. *Indicates significant effect of AGEs compared to control (P < 0.05, t-test).