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. 2012 Oct 18;4(4):1050–1066. doi: 10.3390/cancers4041050

Figure 4.

Figure 4

PRDM14 induces cancer via multifactorial mechanisms. Early changes involve failure of DNA repair mechanisms in the setting of replication stress, though apoptosis mechanisms are active [12]. Subsequent changes involve loss of senescence, deletion of B-cell genes, and/or activation of oncogenes.