Table 2.
Baseline characteristics of patients enrolled as of September 2012 (n=1837).
| Indication | n (% of total) | Male/female (%) | Chronological age, years (mean ± SD) | Bone age, years (mean ± SD) | Median BMI (kg/m2) | Naive/pretreated (%) | Median dose (mg/kg/day) |
|---|---|---|---|---|---|---|---|
| GHD | 1078 (58.7) | 64.8/35.2 | 9.81±3.81 (Nmiss=3) | 8.22±4.00 (Nmiss=739) | 16.10 (Nmiss=259) | 81.1/18.9 | 0.030 |
| SGA | 475 (25.9) | 48.8/51.2 | 8.40±3.35 (Nmiss=2) | 6.55±3.66 (Nmiss=364) | 15.20 (Nmiss=135) | 78.9/21.1 | 0.035 |
| TS | 81 (4.4) | 0/100 | 9.91±4.36 | 8.74±4.34 (Nmiss=63) | 17.40 (Nmiss=22) | 66.7/33.3 | 0.041 |
| PWS | 42 (2.3) | 42.9/57.1 | 3.87±4.24 | 8.08±5.54 (Nmiss=40) | 16.05 (Nmiss=22) | 90.5/9.5 | 0.030 |
| CRI | 12 (0.7) | 41.7/58.3 | 7.17±5.01 | 7.33±4.19 (Nmiss=9) | 16.45 | 83.3/16.7 | 0.047 |
| Other | 111 (6.0) | 60.4/39.6 | 10.39±3.89 | 8.18±4.07 (Nmiss=74) | 16.62 (Nmiss=26) | 81.1/18.9 | 0.035 |
| Not yet recorded | 38 (2.1) | 63.2/36.8 | 9.90±3.45 | 6.25±2.47 (Nmiss=36) | 15.85 (Nmiss=30) | 92.1/7.9 | 0.031 |
| Total | 1837 (100) | 56.9/43.1 | 9.33±3.89 (Nmiss=11) | 7.84±3.99 (Nmiss=1352) | 15.90 (Nmiss=494) | 80.3/19.7 | 0.032 |
GHD, growth hormone deficiency; SGA, small for gestational age; TS, Turner syndrome; PWS, Prader–Willi syndrome; CRI, chronic renal insufficiency; Nmiss, number of patients with data missing.