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. Author manuscript; available in PMC: 2014 Feb 18.
Published in final edited form as: Inorg Chem. 2013 Feb 7;52(4):1701–1709. doi: 10.1021/ic302340c

Scheme 1.

Scheme 1

Synthesis of amino-terminated hexethylene glycol (HEG) linked DOTA ligand 4.

Reagents and conditions: (a) 1.0 eq. MsCl, Et3N, DCM, 0 °C-RT, 3 h; (b) Potassium phthalimide, DMF, 110 °C, 15 h, 44% in two steps; (c) 1.5 eq. MsCl, Et3N, DCM, 0 °C-RT, 3 h; (d) NaI, acetone, 65 °C, 15 h, 95% in two steps; (e) DO3A-t-Bu-ester, KHCO3, DMF, 12 h, RT, 96%; (f) Hydrazine, ethanol, 65 °C, 4 h, 96%.