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Synthesis of 12-fold Gd3+-DOTA closomer conjugate CA-7.
Reagents and conditions: (a) 4, ACN, 7 days, RT, 76%; (b) 80% TFA-DCM, 6 h, RT; (c) GdCl3·6H2O, citrate buffer, pH 7, 24 h, RT, sonication; (d) Dialysis, 1,000 MWCO, 48 h; (e) Lyophilization, 82%.
