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Time-dependent internalization of CCK2 and MOP receptors in CHO-CCK2-YN/MOP-YC cells. Bivalent ligands, compounds 3a, 3b, and 3c, that were able to elicit fluorescent YFP by complementation of the tags on the CHO-CCK2-YN/MOP-YC cells also stimulated the time-dependent internalization of these complexes. Scale bar: 25 μm.
