Table 3. Duration and intensity of statin use and glioma risk.

Statin use	Cases	Controls	Crude odds ratio (95% confidence interval (CI))	Adjusted odds ratioa (95% CI)
Never use	2442	16 879	1 (reference)	1 (reference)
Short-term useb,c
Low intensity	24	179	0.87 (0.57–1.34)	0.94 (0.60–1.47)
Medium intensity	41	250	1.11 (0.79–1.57)	1.10 (0.77–1.56)
High intensity	53	341	1.04 (0.77–1.41)	1.01 (0.73–1.39)
Long-term useb,c
Low intensity	42	352	0.81 (0.58–1.12)	0.81 (0.57–1.14)
Medium intensity	33	273	0.78 (0.54–1.14)	0.86 (0.58–1.26)
High intensity	21	206	0.67 (0.42–1.06)	0.71 (0.44–1.15)

^aAdjusted for years of schooling, diabetes, stroke, and use of aspirin, selective cyclooxygenase 2 (Cox2) inhibitors, and non-aspirin-nonsteroidal anti-inflammatory drugs (NA-NSAIDs).

^bShort term: <5 years of use; long term: 5+ years of use.

^cCutoff values for low-, medium-, and high-intensity statin use defined by tertiles of intensity of use among controls.