Figure 1.

(A–J) Effect of FDA-approved drugs (A–I) and natural compounds (J) on CCID formation. MCF-7 spheroids were placed on LEC monolayers and co-cultivated for 4 h either with medium alone and solvent (DMSO; Co) or with 40 μℳ of the indicated drugs, and then the areas of CCIDs were measured. Asterisks indicate significance (t-test compared with untreated controls; P<0.05) and error bars indicate mean±s.e.m. Black columns indicate the drugs whose activities were confirmed in subsequent dose response experiments (see Figure 2A–D). Grey columns indicate those drugs that turned out to be false positives.