Table 1. Significance of improvement of CCID inhibition by treatment with drug combinations.

	A	N	P	I
A and I	0.0066	—	—	0.0090
N and I	—	0.0016	—	0.0016
P and I	—	—	<0.0001	0.0005
P and A	n.s.	—	n.s.	—
P and N	—	n.s.	n.s.	—
N and A	0.0052	0.0021	—	—
I, A, N and P	<0.0001	<0.0001	<0.0001	<0.0001

Abbreviations: A=acetohexamide; I=isoxsuprine; N=nifedipin; P=proadifen.

The effect of combination treatment versus single-drug treatment on CCID inhibition was analysed by t-test, and the P-values are shown (P<0.05 – significant).