Table 3. (a) Adverse effects associated with preoperative chemotherapy; (b) Adverse effects associated with postoperative chemotherapy.

	FLO (n=22)				FLOT (n=21)				Total (n=43)
	Grade 1/2		Grade 3/4		Grade 1/2		Grade 3/4		Grade 1/2		Grade 3/4
Adverse event	No.	%	No.	%	No.	%	No.	%	No.	%	No.	%	P-valuea
(a)
Haematologic
Leucopenia	8	36.4			9	42.9	7	33.3	17	39.5	7	16.3	<0.0001
Neutropenia	7	31.8	1	4.5	5	23.8	8	38.1	12	27.9	9	20.9	<0.0001
Thrombocytopenia	7	31.8			8	38.1			15	34.9			0.37
Anaemia	19	86.4	1	4.5	12	57.1			31	72.1	1	2.3	0.46
Infection	4	18.2			2	9.5	6	28.6	6	14.0	6	14.0	0.05
Fever	2	9.1			6	28.5			8	18.6			0.07
Non-haematologic
Nausea	16	72.7	1	4.5	16	76.2	5	23.8	32	74.4	6	14.0	0.002
Vomiting	6	27.3	1	4.5	8	38.1	2	9.5	14	32.6	3	7.0	0.48
Fatigue	15	68.2			13	61.9	3	14.3	28	65.1	3	7.0	0.13
Diarrhoea	8	36.4	1	4.5	14	66.7	1	4.8	22	51.2	2	4.7	0.15
Mucositis	7	31.8			9	42.9	3	14.3	16	37.2	3	7.0	0.02
Constipation	8	36.4			5	23.8			13	30.2			0.37
Sensory neuropathy	15	68.2	3	13.6	11	52.4	4	19.0	26	60.5	7	16.3	0.60
Fluid retention	3	13.6			1	4.8			4	9.3			0.95
(b)
Haematologic
Leucopenia	5	45.5			4	44.4	1	11.1	9	45.0	1	5.0	0.25
Neutropenia	4	36.4	1	9.1	2	22.2	4	44.4	6	30.0	5	25.0	0.11
Thrombocytopenia	2	18.2			1	11.1			3	15.0			0.86
Anaemia	11	100			9	100			20	100			0.20
Infection	1	9.1	1	9.1	1	11.1			2	10.0	1	5.0	0.54
Fever	3	27.3			1	11.1			4	20			0.29
Non-haematologic
Nausea	7	63.6			4	44.4	1	11.1	11	55.0	1	5.0	0.87
Vomiting	4	36.4			3	33.3			7	35.0			0.56
Fatigue	8	72.8	1	9.1	5	55.6	1	11.1	13	65	2	10.0	0.17
Diarrhoea	4	36.4			2	22.2	1	11.1	6	30	1	5.0	0.43
Mucositis	1	9.1			1	11.1	2	22.2	2	10.0	2	10.0	0.17
Constipation	1	9.1	1	9.1	1	11.1			2	10.0	1	5.0	0.37
Sensory neuropathy	8	72.7			4	44.4			12	60.0			0.23
Fluid retention

Abbreviation: FLO=oxaliplatin, fluorouracil; FLOT=fluorouracil, oxaliplatin, docetaxel.

^aFisher's exact test was used. P-values are related to the groupings grade 0–2 vs grade 3–4 for FLO vs FLOT.