Table 1. Summary of hazard ratios by cancer site and for age band, and time to cancer diagnosis.
| |
Number of cancers |
Rate per 1000 person years |
|
||||
|---|---|---|---|---|---|---|---|
| Cancer site | Zoster | No zoster | Zoster | No zoster | Hazard ratio | 95% CI | Median time from zoster to cancer (days) (IQR) |
| Combined |
658 |
1396 |
12.08 |
5.10 |
2.42 |
2.21, 2.66 |
815 (387, 1309) |
| Ovary |
20 |
19 |
0.37 |
0.07 |
5.35 |
2.85, 10.03 |
962 (349, 1392) |
| Connective tissue |
8 |
10 |
0.15 |
0.04 |
4.46 |
1.75, 11.40 |
657 (382, 1664) |
| Eye, brain, and other CNS |
8 |
9 |
0.15 |
0.03 |
4.00 |
1.49, 10.75 |
1003 (669, 1314) |
| Oesophagus |
24 |
36 |
0.44 |
0.13 |
3.35 |
2.00, 5.61 |
977 (557, 1331) |
| Oral cavity and pharynx |
7 |
12 |
0.13 |
0.04 |
3.12 |
1.23, 7.97 |
925 (582, 1555) |
| Haematological |
70 |
119 |
1.29 |
0.43 |
3.02 |
2.52, 4.06 |
713 (416, 1130) |
| Lung |
89 |
159 |
1.63 |
0.58 |
2.90 |
2.23, 3.76 |
741 (293, 1205) |
| Breast |
113 |
212 |
2.75 |
0.78 |
2.74 |
2.18, 3.44 |
873 (513, 1262) |
| Cervix and uterus |
18 |
35 |
0.33 |
0.13 |
2.66 |
1.51, 4.70 |
1114 (572, 1571) |
| Pancreas |
20 |
36 |
0.37 |
0.13 |
2.54 |
1.42, 4.53 |
1172 (591, 1484) |
| Prostate |
84 |
172 |
1.54 |
0.63 |
2.49 |
1.92, 3.24 |
750 (368, 1330) |
| Renal |
16 |
18 |
0.29 |
0.07 |
2.32 |
1.13, 4.75 |
1146 (705, 1582) |
| Unknown primary |
39 |
93 |
0.72 |
0.34 |
2.15 |
1.48, 3.13 |
1051 (566, 1435) |
| Melanoma |
17 |
42 |
0.31 |
0.15 |
2.14 |
1.22, 3.77 |
1165 (823, 1452) |
| Colorectal |
83 |
226 |
1.52 |
0.83 |
1.87 |
1.45, 2.40 |
938 (400, 1409) |
| Bladder |
23 |
86 |
0.42 |
0.31 |
1.37 |
0.86, 2.17 |
938 (422, 1420) |
| Miscellaneousa |
9 |
63 |
0.17 |
0.23 |
1.27 |
0.68, 2.39 |
1094 (553, 1435) |
| Hepatocellular/bile duct |
5 |
24 |
0.09 |
0.09 |
1.12 |
0.42, 2.93 |
1105 (827, 1400) |
| Stomach |
5 |
25 |
0.09 |
0.09 |
1.04 |
0.40, 2.72 |
1112 (623, 1431) |
|
Age bands for all cancer types combined (years) | |||||||
| 18–50 | 42 | 33 | 2.73 | 0.45 | 6.57 | 4.18, 10.41 | 1080 (416, 1450) |
| 51–60 | 93 | 175 | 7.86 | 2.94 | 2.72 | 2.12, 3.50 | 884 (513, 1424) |
| 61–70 | 175 | 309 | 14.50 | 5.08 | 2.92 | 2.43, 3.52 | 847 (423, 1419) |
| 71–80 | 228 | 591 | 15.05 | 7.41 | 2.07 | 1.77, 2.41 | 793 (379, 1277) |
| >80 | 120 | 288 | 26.10 | 11.66 | 2.23 | 1.83, 2.81 | 713 (290, 1147) |
Abbreviations: CI=confidence interval; CNS=central nervous system; IQR=interquartile range.
a
The miscellaneous group of cancers included very small numbers of cancers that could not be grouped elsewhere (including and described as thyroid cancer, vagina, penis, adrenal, ‘genitourinary', small intestine, maxillary sinus, pelvic peritoneum, and retroperitoneal).