Table 3. Adenoma recurrences by dietary polyamine intake quartile, and random assignment to DFMO/sulindac or placebo (end-of-study cohort, n=188).
| All patients: dietary polyamine quartiles 1, 2, 3 and4 | Dietary polyamine quartile 1 (lowest) | Dietary polyamine quartile 2 | Dietary polyamine quartile 3 | Dietary polyamine quartile 4 (highest) | |
|---|---|---|---|---|---|
| (n=188) | (n=47) | (n=47) | (n=47) | (n=47) | |
|
Adenoma recurrences | |||||
| DFMO+sulindac (n=94) |
12/94 (12.8%) |
3/24 (12.5%) |
1/24 (4.2%) |
3/21 (14.3%) |
5/25 (20.0%) |
| Placebo (n=94) |
42/94 (44.7%) |
11/23 (47.8%) |
11/23 (47.8%) |
14/26 (53.9%) |
6/22 (27.3%) |
| P-value | <0.0001 | 0.008 | 0.0006 | 0.005 | 0.56 |
Abbreviation: DFMO=difluoromethylornithine.Values denote number of recurrences/number at risk (%).