Figure 13.

Example of typical Windkessel controlled isolated supported ventricle (WCISV) dataset. Experimental protocol consisted of first determining control values for the distal vascular resistance, characteristic impedance, and arterial compliance of the normal animal; which were 3.0 mmHg-s/ml, 0.2 mmHg-s/ml, and 0.4 ml/mmHg, respectively, for dogs weighing 20 to 22 kg. Arterial compliance and resistance were varied by 50% and 200% of control values while P-V loops were generated at four end-diastolic volumes for each experimental condition. Characteristic impedance was kept at control value. Heart rate was kept constant during all experiments (127 ± 9 beats/min) by pacing. Solid line at control indicates P-V relationship at control conditions, dashed lines in other panels indicate transcribed P-V relationship line from control. (B) and (C) End-systolic pressure versus stroke with varying resistance and capacitance, symbols represent experimental data (137).