Table 2.
Motif No. | Public CDR3α motif | Donors and previous reports in which public motif was found | Prevalence among all responses in this study (%) |
---|---|---|---|
1 | *nGNQF | Y2, E3, E4, Trautmann, et al. (23), Day, et al. (25) | 14.1 |
2 | *nYGQNF | Y1, E2, Trautmann, et al. (23), Day, et al. (25) | 2.1 |
3 | *nNNNDM | Y2, E2, E4, Trautmann, et al. (23) | 10.5 |
4 | *nNFGNEKL | E2, Trautmann, et al. (23) | 2.1 |
5 | *nTGANNL | Y1, E2, Trautmann, et al. (23) | 1.6 |
6 | *nTGGGNKL | Y1, E4 | 5.1 |
7 | *nTSYDKV | E2, Trautmann, et al. (23) | 1.6 |
| |||
Public CDR3β motif | |||
| |||
8 | S*nTG*nGY | Y2, E1, E2, E4, Weekes, et al. (21), Trautmann, et al. (23), Price, et al. (24), Day, et al. (25), Khan, et al. (22) | 13.0 |
9 | S*nTEA | Y1, E2, E4, Weekes, et al. (21), Trautmann, et al. (23), Price, et al. (24), Day, et al. (25), Khan, et al. (22), Venturi, et al. (27) | 11.7 |
10 | *nTDTQ | Y1, Trautmann, et al. (23), Price, et al. (24), Day, et al. (25) | 4.3 |
11 | *nRD*nG*YEQ | E3, Day, et al. (25), Khan, et al. (22) | 9.7 |
12 | *nSYEQ | Y1, E2, Weekes, et al. (21), Price, et al. (24), Khan, et al. (22) | 1.5 |
13 | *nTSGALYNEQ | E3, Trautmann, et al. (23) | 6.1 |
*n denotes a variable region of the public motif consisting of n amino acids, where n can range from 1 to 10. Percentages in this table are derived from all responses (N = 297 TCR sequences), regardless of whether TCRα and β co-expression data are available.