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. 2013 Mar 1;30(5):382–391. doi: 10.1089/neu.2012.2536

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Copyright 2013, Mary Ann Liebert, Inc.

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FIG. 5. — Morris water maze performance after single and sequential controlled cortical impact (CCI) and closed head injury (CHI). (A) Sham-injured CCI and CHI groups did not differ with respect to performance in hidden and visible platform trials. (B) CCI (p<0.05 for group) but not CHI (53 g) alone produced hidden platform deficits compared with shams. Hidden platform deficits in CCI alone and in both sequential models (CCI-CHI 53 g and CHI 53 g-CCI) were greater than those observed in CHI (53 g) alone (p<0.05 for group), but no differences were observed among CCI-CHI (53 g), CHI (53 g)-CCI, and CCI groups. Likewise, no differences in visible platform (p>0.05 for group). (C) CCI-CHI (83 g) mice had hidden platform deficits compared with CCI alone (p<0.005 for group), indicating an additive effect of CHI (83 g) to that of CCI in the sequential injury group.