Table 3.

Currently Available Serological Markers Assessing the Structure of the Extracellular Matrix

Name of protein fragment	ECM component	Reference
C1M	MMP-mediated type I collagen degradation	198
C2M	MMP-mediated type II collagen degradation	56
C3M	MMP-mediated type III collagen degradation	60
C4M	MMP-mediated type IV collagen degradation	197
C5M	MMP-mediated type V collagen degradation	331
C6M	MMP-mediated type VI collagen degradation	200
P1NP	Type I collagen formation in tissues other than bone	144
P4NP 7S	Type IV collagen formation	196
P5CP	Type V collagen formation	199
PIIANP	Type II collagen formation	332,333
PIIINP	Type III collagen formation	334
VICM	MMP-mediated citrullinated vimentin degradation	335
CRPM	MMP-mediated CRP degradation	274
ELM	MMP-mediated elastin degradation	217
BGM	MMP-mediated biglycan degradation	336
MIM	MMP-mediated mimican degradation	129
VCANM	MMP-mediated versican degradation	337
TIM	MMP-mediated titin degradation	338
Aggrecan	MMP- and aggrenase-cleaved aggrecan	278
COMP	Intact COMP	339
Osteocalcin	Intact osteocalcin bone formation	340
HA	Hyalonic acid	334
ICTP	MMP-mediated type I collagen destruction	314
CTX-I	Cathepsin K degraded type I collagen	276,311,341,342
CTX-II	MMP-degraded type II collagen	343,344
C2C	MMP-degraded type II collagen	345
TELO-I	Citrullinated carboxyterminal telopeptides of type I collagen	346
TELO-II	Citrullinated carboxyterminal telopeptides of type II collagen	346
MCV	Mutated citrullinated vimentin	347

ECM, extracellular matrix; MMP, matrix metalloproteinase; CRP, C-reactive protein.