Table 4.
List of Post-Translational Modifications Involved in Immune Responses in Different Autoimmune Diseases
| Autoantigen | Relevant disease/animal model | Modification | Reference |
|---|---|---|---|
| MBP | MS/EAE | Acetylation | 376 |
| Citrullination | 377 | ||
| Isomerization | 296 | ||
| Phosphorylation | 378 | ||
| aB-crystallin | MS/EAE | Citrullination | 379,380 |
| Isomerization | 321 | ||
| Phosphorylation | 381 | ||
| Type I collagen | RA | Citrullination | 346 |
| Type II collagen | RA/CIA | Glycosylation | 382 |
| Protease degradation | 311 | ||
| Hydroxylation | 382 | ||
| Citrullination | 346 | ||
| Fibrin | RA | Citrullination | 383 |
| Fillagrin | RA | Citrullination | 384 |
| Vimentin | RA | Citrullination | 347,385 |
| IgG | RA | Isomerization | 296 |
| Glycation | 386 | ||
| Insulin | Type I diabetes | Deamidation | 319 |
| Isomerization | 319 | ||
| GAD | Type I diabetes | Oxidative damage | 387 |
| Histone H2B | SLE | Isomerization | 322 |
| Deamidation | 388 | ||
| Transglutamination | 388 | ||
| SnRNP D | SLE | Isomerization | 320 |
| SnRNP 70k | SLE | Phosphorylation | 389 |
MS, multiple sclerosis; EAE, experimental autoimmune ecephalomyelitis; RA, rheumatoid arthritis; CIA, collagen-induced arthritis; SLE, systemic lupus erythematosus.