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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: J Mol Cell Cardiol. 2013 Jan 31;57:68–71. doi: 10.1016/j.yjmcc.2013.01.010

Fig. 1.

Fig. 1

Schematics of the alternative topologies of NCX1. Panel A shows the currently accepted 9 TMS arrangement of NCX1, and panel B shows the 10 TMS topology as predicted by the crystal structure of the archaebacterial NCX_Mj. Circled numbers indicate locations of cysteines used in this study. Dotted lines indicate the predicted crosslinks with each model. The heavy line between TMSs 7 and 8 in panel A is the region that becomes the new TMS8 in panel B (designated with an asterisk). Note that TMSs 8 and 9 in the nine TMS model reverse orientation and become TMSs 9 and 10 in the ten TMS model.