Fig 3.

Effects of minocycline or its vehicle on group mean infusions of methamphetamine (0.001, 0.03, and 0.1 mg/kg/inf) obtained during daily 2-h self-administration sessions. Minocycline was administered at 10, 30, or 60 mg/kg i.p once daily for 3 consecutive days at each methamphetamine self-administered dose. Data points represent the group means of total infusions obtained during the third day of testing at each minocycline dose. Bars through symbols indicate ±S.E.M. Data point above "S" on the abscissa indicates results when saline was self-administered when minocycline's vehicle (saline) was given daily. N = 5 rats. *p < 0.05 with respect to infusions obtained under minocycline's vehicle condition.