Figure 6.
Example of cone photoreceptor density analysis from a Category II dry AMD patient (A) cone photoreceptor mosaic (3° × 1°, ~ 0.87 mm × 0.29 mm) (B) Automated identification of cone photoreceptor locations reveal areas of suspected degeneration or loss of functionality (C) Heat map of localized photoreceptor densities in 0.25° × 0.25° regions to provide a broad assessment of changes associated with AMD, dark regions represent lower relative photoreceptor density [values range from 2568 – 13983 cones/mm2; mean value ± SD: 8698 ± 2964] (D) Voronoi diagram demonstrating the relationship between photoreceptor packing density and alterations caused by drusen formation. Deviations in the expected cellular organization can easily be seen using these complimentary depictions. [Scale bar = 0.1 mm]