Skip to main content
. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Fitoterapia. 2013 Jan 17;85:84–94. doi: 10.1016/j.fitote.2013.01.003

Table 4.

Effect of administration of HS extract on animal total cholesterol, HDL-C, LDL-C and triglycerides.

Primary
author, year		 Condition Sample
size		 Plant
Part		 Extract
mode		 Dose End
time
point		 Within
group
TC		 Between
group TC		 Within
group
HDL-C		 Between
group
HDL-C		 Within
group
LDL-C		 Between
group
LDL-C		 Within
group
TG		 Between
group TG
Olatunji, 2005 None 6 rats Pa W 1a 28 NS NS Dep NS
Olatunji, 2005 None 6 rats Pb W 1a 28 NS NS Dep NS
Olatunji, 2005 None 6 rats Pa W 1.5a 28 Dep NS Dep NS
Olatunji, 2005 None 6 rats Pb W 1.5a 28 Dep NS Dep NS
Farombi, 2007 None 5 rats F A 100a 28 NS NS N/A NS
Farombi, 2007 None 5 rats F A 200a 28 Dep NS N/A Dep
Peng, 2011 None 8 rats C A 200a 63 NS N/A N/A NS
Chen, 2003 Hyper 6 rabbits N/A W 0.5b 70 Dep NS Dep Dep
Chen, 2003 Hyper 6 rabbits N/A W 1b 70 Dep NS Dep Dep
El-Saadany, 1991 Hyper 6 rats C N/A 5b 63 Dep N/A N/A Dep
El-Saadany, 1991 Hyper 6 rats C N/A 10b 63 Dep N/A N/A Dep
Hirunpanich, 2006 Hyper 6 rats C W 250a 42 NS Dep NS NS NS Dep NS NS
Hirunpanich, 2006 Hyper 6 rats C W 500a 42 Red Dep NS NS Red NS Red Dep
Hirunpanich, 2006 Hyper 6 rats C W 1000a 42 Red Dep NS NS Red Dep Red NS
Chen, 2004 Hyper 6 rats F W 10000a 84 Dep NS Dep NS
Chen, 2004 Hyper 6 rats F W 20000a 84 Dep NS Dep NS
Carvajal-Zarrabal, 2005 Hyper N/A rats C A 5c 28 Dep NS Dep Dep
Carvajal-Zarrabal, 2005 Hyper N/A rats C A 10c 28 NS NS Dep Dep
Carvajal-Zarrabal, 2005 Hyper N/A rats C A 15c 28 NS NS Dep Dep
Peng, 2011 Hyper 8 rats C A 100a 63 NS N/A N/A Dep
Peng, 2011 Hyper 8 rats C A 200a 63 Dep N/A N/A Dep
Ochani, 2009 Hyper 6 rats C A 500a 30 Dep Ele Dep Dep
Gosain, 2010 Hyper 6 rats L A 100a 28 NS NS NS NS NS NS NS NS
Gosain, 2010 Hyper 6 rats L A 200a 28 Red Dep NS NS Red Dep Red Dep
Gosain, 2010 Hyper 6 rats L A 300a 28 Red Dep NS NS Red Dep Red Dep
Ochani, 2009 Hyper 6 rats L A 500a 30 Dep Ele Dep Dep
Farombi, 2007 Diab 5 rats F A 100a 28 Dep NS N/A NS
Farombi, 2007 Diab 5 rats F A 200a 28 Dep NS N/A NS
Lee, 2009 Diab 5 rats F A 100a 56 Dep NS Dep Dep
Lee, 2009 Diab 5 rats F A 200a 56 Dep NS Dep Dep
Peng, 2011 Hyper, diab 8 rats C A 100a 63 NS N/A N/A Dep
Peng, 2011 Hyper, diab 8 rats C A 200a 63 Dep N/A N/A Dep

Notes: Condition: Hyper=hyperlipidemia, Diab=diabetes; Plant part used in extract=F=flower, C=calyx, P=petal, L=leaf, a=red, b=green; Extract mode: W=water, A=alcohol;

Dose: a=mg of HS extract/kg weight of animal/day,

b

%,

c

g extract/100 g basal diet; End time point: number of days after start of treatment when measurement was taken; TC=total cholesterol, HDL-C=high-density lipoprotein cholesterol, LDL-C=low-density lipoprotein cholesterol, TG=triglycerides; Results: N/A=not available, NS=not significant, Dep=depressed, Ele=elevated, Red=reduced, Inc=increased, Depressed or elevated used accordingly when values compared with appropriate control, increased or reduced used when values compared between baseline and end of treatment within the same group