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. Author manuscript; available in PMC: 2013 Sep 15.
Published in final edited form as: J Immunol. 2013 Feb 8;190(6):2527–2535. doi: 10.4049/jimmunol.1202928

Figure 5. E613R but not H/− mice develop autoimmunity on a susceptible genetic background.

Figure 5

(A) Graph representing anti-dsDNA IgG antibodies assessed by ELISA in serum of 6 month old H/−, CD45+/+, and E613R B6/129 F1 mice. AEU = arbitrary elisa units. Values are mean ± SEM of 8–10 mice.

(B) Graph representing urine protein assessed by dipstick in 6 month old H/−, CD45+/+, and E613R B6/129 F1 mice. Values are mean ± SEM of 8–10 mice.

(C) Kaplan-Meier curve depicts survival of a cohort of H/−, CD45+/+, and E613R B6/129 F1 mice, N=10 per genotype.

(D) Hematoxylin and eosin staining of formalin fixed kidney sections from H/− and E613R B6/129 F1 mice at 8 months of age. Representative specimens at 10X and 20X magnification are depicted.

(E) Graph representing serum BAFF (ng/ml) assessed by ELISA in 6 month old H/−, CD45+/+, and E613R B6/129 F1 mice. Values are mean ± SEM of 8–10 mice.

(F) Representative spleens from 8 month old H/−, CD45+/+, and E613R B6/129 F1 mice.