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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Wiley Interdiscip Rev Dev Biol. 2012 May 29;2(2):229–245. doi: 10.1002/wdev.67

Figure 6.

Figure 6

CDK5 phosphorylation substrates during neuronal migration. When CDK5 is activated by binding of CDK5R1 (p35)/CDK5R2 (p39), this kinase phosphorylates multiple substrates in migrating neurons. Among those substrates, DCX, NDEL1, MTAP1B and PTK2 (FAK) are MT-regulating proteins. A very interesting phosphorylation substrate of CDK5 is CDKN1B (p27kip1). P-CDKN1B suppresses RHOA GTPase activity. RHOA-ROCK-LIMK1-CFL1 and RHOA-ROCK-MLC signaling pathway have been implicated in actin cytoskeletal remodeling during neuronal migration. CDK5 indirectly affects these actin-regulating signaling pathways by modulating CDK5N1B function. (Blue proteins: MT regulators, red proteins: actin regulators)