Fig. 3.

Glucose-stimulated insulin secretion is increased in aldosterone-deficient mice during normal chow and HF feeding. During hyperglycaemic clamp conditions, glucose was infused to achieve equivalent hyperglycaemia in normal-chow-fed wild-type (white circles) and aldosterone-deficient (white triangles) mice and HF-fed wild-type (black circles) and As^−/− mice (black triangles) (a). Plasma insulin (b) and C-peptide (c) concentrations were significantly higher in As^−/− mice during either normal chow or HF feeding than in wild-type. *p≤0.05 vs wild-type; ^†p≤0.05 vs wild-type + HF; ^‡p≤0.05 vs As^−/−