Fig. 6.

Obesity-induced adipokine dysfunction is prevented in aldosterone-deficient mice. Plasma adiponectin increased during HF feeding to a greater extent in As^−/− than wild-type mice (a). Quantification of adiponectin oligomers revealed a selective increase in HMW adiponectin during HF feeding, which increased to a greater extent in As^−/− mice. A representative western blot of plasma HMW adiponectin oligomers is shown (b). Plasma leptin increased significantly during HF feeding, to a greater extent in As^−/− than wild-type mice (c). *p<0.05, **p≤0.01, ***p≤0.001